Efficacy and safety of an intranasal virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice and cotton rats

www.elsevier.com/locate/vaccine, available online 13 March 2013

Respiratory syncytial virus (RSV) infection causes viral bronchiolitis in infants and young children but also significant health problem in the elderly and immune-compromised individuals. RSV infection at young age does not lead to life-long protection and multiple reinfections occur throughout life. Vaccination of risk groups would be an effective approach to reduce the burden of disease. Although RSV has been recognized as an important vaccine target, no vaccine is available.

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